UPF3A antibody (AA 327-476)

Catalog No. ABIN7271227

Product Details anti-UPF3A Antibody

Target: UPF3A (UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))

Binding Specificity: AA 327-476

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UPF3A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: UPF3A Rabbit pAb

Sequence: EGSLEEPQET SHSGSDKEHR DVERSQEQES EAQRYHVDDG RRHRAHHEPE RLSRRSEDEQ RWGKGPGQDR GKKGSQDSGA PGEAMERLGR AQRCDDSPAP RKERLANKDR PALQLYDPGA RFRARECGGN RRICKAEGSG TGPEKREEAE

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 327-476 of human UPF3A (NP_075387.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UPF3A

Target: UPF3A (UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))

Alternative Name: UPF3A (UPF3A Products)

Synonyms: 2600001C03Rik antibody, 4930546M19Rik antibody, RENT3A antibody, UPF3 antibody, UPF3A antibody, HUPF3A antibody, si:dkey-21o13.6 antibody, UPF3 regulator of nonsense transcripts homolog A (yeast) antibody, UPF3A, regulator of nonsense mediated mRNA decay antibody, Upf3a antibody, UPF3A antibody, upf3a antibody

Background: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene.,UPF3A,HUPF3A,RENT3A,UPF3,Epigenetics & Nuclear Signaling,Signal Transduction,UPF3A

Molecular Weight: 17kDa/51kDa/54kDa

Gene ID: 65110

UniProt: Q9H1J1