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TXK antibody (AA 1-180)

TXK Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7271114
  • Target See all TXK Antibodies
    TXK (TXK tyrosine Kinase (TXK))
    Binding Specificity
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    AA 1-180
    Reactivity
    • 25
    • 2
    • 2
    Human
    Host
    • 23
    • 3
    • 1
    Rabbit
    Clonality
    • 24
    • 3
    Polyclonal
    Conjugate
    • 12
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TXK antibody is un-conjugated
    Application
    • 16
    • 15
    • 11
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    TXK Rabbit pAb
    Sequence
    MILSSYNTIQ SVFCCCCCCS VQKRQMRTQI SLSTDEELPE KYTQRRRPWL SQLSNKKQSN TGRVQPSKRK PLPPLPPSEV AEEKIQVKAL YDFLPREPCN LALRRAEEYL ILEKYNPHWW KARDRLGNEG LIPSNYVTEN KITNLEIYEW YHRNITRNQA EHLLRQESKE GAFIVRDSRH
    Cross-Reactivity
    Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human TXK (NP_003319.2).
    Isotype
    IgG
    Top Product
    Discover our top product TXK Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    TXK (TXK tyrosine Kinase (TXK))
    Alternative Name
    TXK (TXK Products)
    Synonyms
    BTKL antibody, PSCTK5 antibody, PTK4 antibody, RLK antibody, TKL antibody, A130089B16Rik antibody, Btkl antibody, Rlk antibody, TXK tyrosine kinase antibody, tyrosine-protein kinase TXK antibody, TXK antibody, Txk antibody, LOC100544958 antibody
    Background
    Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC activate T-cell receptor (TCR, a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1. Within the complex, phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.,TXK,BTKL,PSCTK5,PTK4,RLK,TKL,Epigenetics & Nuclear Signaling,Signal Transduction,Kinase,Tyrosine kinases,Immunology & Inflammation,Cytokines,Interferons,Cell Intrinsic Innate Immunity Signaling Pathway,TXK
    Molecular Weight
    61kDa
    Gene ID
    7294
    UniProt
    P42681
    Pathways
    Regulation of Leukocyte Mediated Immunity, Hepatitis C
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