TRMT112 antibody (AA 1-125)

Catalog No. ABIN7271001

This anti-TRMT112 antibody is a Rabbit Polyclonal antibody detecting TRMT112 in WB. Suitable for Human.

Quick Overview for TRMT112 antibody (AA 1-125) (ABIN7271001)

Target: TRMT112 (tRNA Methyltransferase 11-2 (TRMT112))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRMT112 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRMT112 Antibody

Binding Specificity: AA 1-125

Purpose: TRMT112 Rabbit pAb

Sequence: MKLLTHNLLS SHVRGVGSRG FPLRLQATEV RICPVEFNPN FVARMIPKVE WSAFLEAADN LRLIQVPKGP VEGYEENEEF LRTMHHLLLE VEVIEGTLQC PESGRMFPIS RGIPNMLLSE EETES

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human TRMT112 (NP_057488.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TRMT112

Target: TRMT112 (tRNA Methyltransferase 11-2 (TRMT112))

Alternative Name: TRMT112

Background: Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7 position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with HEMK2/N6AMT1 also monomethylates 'Lys-12' of histone H4 (H4K12me1. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production. Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA.,TRMT112,HSPC152,HSPC170,TRM112,TRMT11-2,hTrm112,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,TRMT112

Molecular Weight: 13kDa/14kDa

Gene ID: 51504

UniProt: Q9UI30