TMED2 antibody (AA 60-170)

Catalog No. ABIN7270943

Product Details anti-TMED2 Antibody

Target: TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))

Binding Specificity: AA 60-170

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMED2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: TMED2 Rabbit pAb

Sequence: EITGPDNKGI YKGDRESSGK YTFAAHMDGT YKFCFSNRMS TMTPKIVMFT IDIGEAPKGQ DMETEAHQNK LEEMINELAV AMTAVKHEQE YMEVRERIHR AINDNTNSRV V

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TMED2

Target: TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))

Alternative Name: TMED2 (TMED2 Products)

Synonyms: P24A antibody, RNP24 antibody, p24 antibody, 1110032D12Rik antibody, 1810020N21Rik antibody, Rnp24 antibody, Sid394 antibody, p24beta1 antibody, Chop24 antibody, transmembrane p24 trafficking protein 2 antibody, TMED2 antibody, Tmed2 antibody

Background: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor, the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs. Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.,P24A,RNP24,p24,p24b1,p24beta1,TMED2,Signal Transduction,Cell Biology & Developmental Biology,TMED2

Molecular Weight: 22kDa

Gene ID: 10959

UniProt: Q15363