TOP1MT antibody (AA 470-550)

Catalog No. ABIN7270851

Product Details anti-TOP1MT Antibody

Target: TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))

Binding Specificity: AA 470-550

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOP1MT antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Purpose: TOP1MT Rabbit pAb

Sequence: RATPSTFEKS MQNLQTKIQA KKEQVAEARA ELRRARAEHK AQGDGKSRSV LEKKRRLLEK LQEQLAQLSV QATDKEENKQ V

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 470-550 of human TOP1MT (NP_443195.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TOP1MT

Target: TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))

Alternative Name: TOP1MT (TOP1MT Products)

Background: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.,TOP1MT,Epigenetics & Nuclear Signaling,Cancer,Drug resistance,Topoisomerases,TOP1MT

Molecular Weight: 58kDa/69kDa

Gene ID: 116447

UniProt: Q969P6