TNKS2 antibody (AA 780-1050)

Catalog No. ABIN7270726

This Rabbit Polyclonal antibody specifically detects TNKS2 in WB. It exhibits reactivity toward Human.

Quick Overview for TNKS2 antibody (AA 780-1050) (ABIN7270726)

Target: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNKS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TNKS2 Antibody

Binding Specificity: AA 780-1050

Purpose: TNKS2 Rabbit pAb

Sequence: TPLDLVSADD VSALLTAAMP PSALPSCYKP QVLNGVRSPG ATADALSSGP SSPSSLSAAS SLDNLSGSFS ELSSVVSSSG TEGASSLEKK EVPGVDFSIT QFVRNLGLEH LMDIFEREQI TLDVLVEMGH KELKEIGINA YGHRHKLIKG VERLISGQQG LNPYLTLNTS GSGTILIDLS PDDKEFQSVE EEMQSTVREH RDGGHAGGIF NRYNILKIQK VCNKKLWERY THRRKEVSEE NHNHANERML FHGSPFVNAI IHKGFDERHA Y

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 780-1050 of human TNKS2 (NP_079511.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TNKS2

Target: TNKS2 (Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2))

Alternative Name: TNKS2

Background: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.,TNKS2,ARTD6,PARP-5b,PARP-5c,PARP5B,PARP5C,TANK2,TNKL,pART6,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Wnt/β-Catenin Signaling Pathway,TNKS2

Molecular Weight: 126kDa

Gene ID: 80351

UniProt: Q9H2K2