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SYNGAP1 antibody

SYNGAP1 Reactivity: Human WB Host: Rabbit Monoclonal unconjugated
Catalog No. ABIN7270663
  • Target See all SYNGAP1 Antibodies
    SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))
    Reactivity
    • 20
    • 16
    • 14
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 19
    • 2
    Rabbit
    Clonality
    • 19
    • 2
    Monoclonal
    Conjugate
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SYNGAP1 antibody is un-conjugated
    Application
    • 10
    • 8
    • 5
    • 2
    • 2
    Western Blotting (WB)
    Purpose
    SynGAP Rabbit mAb
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Monoclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    A synthesized peptide derived from human SynGAP
    Isotype
    IgG
    Top Product
    Discover our top product SYNGAP1 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))
    Alternative Name
    SYNGAP1 (SYNGAP1 Products)
    Synonyms
    SYNGAP1 antibody, Syngap antibody, MRD5 antibody, RASA1 antibody, RASA5 antibody, SYNGAP antibody, Gm1963 antibody, synaptic Ras GTPase activating protein 1 antibody, zinc finger and BTB domain containing 9 antibody, synaptic Ras GTPase activating protein 1 homolog (rat) antibody, SYNGAP1 antibody, ZBTB9 antibody, syngap1 antibody, Syngap1 antibody
    Background
    This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016],MRD5, RASA1, RASA5, SYNGAP,Cell Type Marker,Cell Type Marker_Neuron marker,Cell Type Marker_Synapse marker,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,Neuroscience,Signal Transduction,SYNGAP1
    Molecular Weight
    147kDa
    Gene ID
    8831
    UniProt
    Q96PV0
    Pathways
    Regulation of long-term Neuronal Synaptic Plasticity
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