SKAP2 antibody (AA 1-120)

Catalog No. ABIN7270564

Product Details anti-SKAP2 Antibody

Target: SKAP2 (Src Kinase Associated Phosphoprotein 2 (SKAP2))

Binding Specificity: AA 1-120

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SKAP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: SKAP2 Rabbit pAb

Sequence: MPNPSSTSSP YPLPEEIRNL LADVETFVAD ILKGENLSKK AKEKRESLIK KIKDVKSIYL QEFQDKGDAE DGEEYDDPFA GPPDTISLAS ERYDKDDEAP SDGAQFPPIA AQDLPFVLKA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SKAP2 (NP_003921.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SKAP2

Target: SKAP2 (Src Kinase Associated Phosphoprotein 2 (SKAP2))

Alternative Name: SKAP2 (SKAP2 Products)

Background: The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.,SKAP2,PRAP,RA70,SAPS,SCAP2,SKAP-HOM,SKAP55R,Signal Transduction,Kinase,Tyrosine kinases,SKAP2

Molecular Weight: 41kDa

Gene ID: 8935

UniProt: O75563