SPRY3 antibody (C-Term)

Catalog No. ABIN7270556

Product Details anti-SPRY3 Antibody

Target: SPRY3 (Sprouty Homolog 3 (SPRY3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPRY3 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: SPRY3 Rabbit pAb

Sequence: TDDEDNCADE PCSCGPSSCF VRWAAMSLIS LFLPCLCCYL PTRGCLHLCQ QGYDSLRRPG CRCKRHTNTV CRKISSGSAP FPKAQEKSV

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human SPRY3 (NP_005831.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SPRY3

Target: SPRY3 (Sprouty Homolog 3 (SPRY3))

Alternative Name: SPRY3 (SPRY3 Products)

Synonyms: HSPRY3 antibody, spry-3 antibody, Gm1409 antibody, Gm391 antibody, sprouty3 antibody, RGD1562172 antibody, sprouty RTK signaling antagonist 3 antibody, sprouty homolog 3 (Drosophila) antibody, SPRY3 antibody, Spry3 antibody

Background: Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well-conserved cysteine-rich carboxy-terminal domain with their Drosophila counterparts. Sprouty proteins are cytoplasmic in unstimulated cells, but in cells stimulated by growth factors they anchor to the plasma membrane by palmitoylation. Sprouty 1 and 2 associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on serine residues. Sprouty 2 can associate with c-Cbl, a downregulator of RTK signaling, and inhibit the activities of several growth factors. Unlike the widely expressed Sprouty members 1, 2 and 4, Sprouty 3 expression is restricted to adult brain and testis. Sprouty 4 is a target of the WNT/b-catenin signaling pathway in progenitor cells. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes.,SPRY3,spry-3,Signal Transduction,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,SPRY3

Molecular Weight: 31kDa

Gene ID: 10251

UniProt: O43610