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SPRY3 antibody (C-Term)

SPRY3 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7270556
  • Target See all SPRY3 Antibodies
    SPRY3 (Sprouty Homolog 3 (SPRY3))
    Binding Specificity
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 9
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Human
    Host
    • 10
    • 1
    Rabbit
    Clonality
    • 11
    Polyclonal
    Conjugate
    • 11
    This SPRY3 antibody is un-conjugated
    Application
    • 11
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Purpose
    SPRY3 Rabbit pAb
    Sequence
    TDDEDNCADE PCSCGPSSCF VRWAAMSLIS LFLPCLCCYL PTRGCLHLCQ QGYDSLRRPG CRCKRHTNTV CRKISSGSAP FPKAQEKSV
    Cross-Reactivity
    Human
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human SPRY3 (NP_005831.1).
    Isotype
    IgG
    Top Product
    Discover our top product SPRY3 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SPRY3 (Sprouty Homolog 3 (SPRY3))
    Alternative Name
    SPRY3 (SPRY3 Products)
    Synonyms
    HSPRY3 antibody, spry-3 antibody, Gm1409 antibody, Gm391 antibody, sprouty3 antibody, RGD1562172 antibody, sprouty RTK signaling antagonist 3 antibody, sprouty homolog 3 (Drosophila) antibody, SPRY3 antibody, Spry3 antibody
    Background
    Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well-conserved cysteine-rich carboxy-terminal domain with their Drosophila counterparts. Sprouty proteins are cytoplasmic in unstimulated cells, but in cells stimulated by growth factors they anchor to the plasma membrane by palmitoylation. Sprouty 1 and 2 associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on serine residues. Sprouty 2 can associate with c-Cbl, a downregulator of RTK signaling, and inhibit the activities of several growth factors. Unlike the widely expressed Sprouty members 1, 2 and 4, Sprouty 3 expression is restricted to adult brain and testis. Sprouty 4 is a target of the WNT/b-catenin signaling pathway in progenitor cells. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes.,SPRY3,spry-3,Signal Transduction,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,SPRY3
    Molecular Weight
    31kDa
    Gene ID
    10251
    UniProt
    O43610
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