SPIRE2 antibody (AA 1-190)

Catalog No. ABIN7270538

Product Details anti-SPIRE2 Antibody

Target: SPIRE2 (Spire Homolog 2 (SPIRE2))

Binding Specificity: AA 1-190

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPIRE2 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: SPIRE2 Rabbit pAb

Sequence: MARAGSCGGA AAGAGRPEPW ELSLEEVLKA YEQPLNEEQA WAVCFQGCRG LRGSPGRRLR DTGDLLLRGD GSVGAREPEA AEPATMVVPL ASSEAQTVQS LGFAIYRALD WGLDESEERE LSPQLERLID LMANNDSEDS GCGAADEGYG GPEEEEEAEG VPRSVRTFAQ AMRLCAARLT DPRGAQAHYQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human SPIRE2 (NP_115827.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SPIRE2

Target: SPIRE2 (Spire Homolog 2 (SPIRE2))

Alternative Name: SPIRE2 (SPIRE2 Products)

Synonyms: BC026502 antibody, Spir-2 antibody, Spir2 antibody, spire-type actin nucleation factor 2 antibody, spire homolog 2 (Drosophila) antibody, spire type actin nucleation factor 2 antibody, Spire2 antibody, SPIRE2 antibody

Background: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage.,SPIRE2,Spir-2,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,SPIRE2

Molecular Weight: 65kDa/74kDa/79kDa

Gene ID: 84501

UniProt: Q8WWL2