TNNI1 antibody

Catalog No. ABIN7270338

Product Details anti-TNNI1 Antibody

Target: TNNI1 (Slow Skeletal Troponin I (TNNI1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TNNI1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Troponin I1/TnI1 Rabbit mAb

Cross-Reactivity: Human, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Troponin I1/TnI1

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TNNI1

Target: TNNI1 (Slow Skeletal Troponin I (TNNI1))

Alternative Name: TNNI1 (TNNI1 Products)

Background: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008],SSTNI, TNN1,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Microfilaments,Signal Transduction,TNNI1

Molecular Weight: 22kDa

Gene ID: 7135

UniProt: P19237