SETD7 antibody
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- Target See all SETD7 Antibodies
- SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This SETD7 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purpose
- SETD7 Rabbit mAb
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Monoclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- A synthesized peptide derived from human SETD7
- Isotype
- IgG
- Top Product
- Discover our top product SETD7 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
- Alternative Name
- SETD7 (SETD7 Products)
- Background
- Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.,KMT7, SET7, SET7/9, SET9,Epigenetic writers and erasers of core Histones,Epigenetic writers and erasers of core Histones_Methylation,Epigenetics & Nuclear Signaling,SETD7
- Molecular Weight
- 41kDa
- Gene ID
- 80854
- UniProt
- Q8WTS6
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