Selenoprotein S antibody (AA 50-150)

Catalog No. ABIN7270197

Product Details anti-Selenoprotein S Antibody

Target: Selenoprotein S (SELS)

Binding Specificity: AA 50-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Selenoprotein S antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: VIMP Rabbit pAb

Sequence: KLSARLRALR QRQLDRAAAA VEPDVVVKRQ EALAAARLKM QEELNAQVEK HKEKLKQLEE EKRRQKIEMW DSMQEGKSYK GNAKKPQEED SPGPSTSSVL K

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human VIMP (NP_982298.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Selenoprotein S

Target: Selenoprotein S (SELS)

Alternative Name: SELENOS (SELS Products)

Synonyms: ADO15 antibody, SBBI8 antibody, SELS antibody, SEPS1 antibody, 1500011E07Rik antibody, C78786 antibody, H-4 antibody, H-47 antibody, H4 antibody, H47 antibody, Sels antibody, sg2 antibody, selenoprotein S antibody, SELENOS antibody, Selenos antibody

Background: This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR have been shown to function as modulators of Sec insertion in this protein (PMID:23614019). An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene.,SELENOS,AD-015,ADO15,SBBI8,SELS,SEPS1,VIMP,Signal Transduction,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,SELENOS

Molecular Weight: 21kDa

Gene ID: 55829

UniProt: Q9BQE4

Pathways: Cellular Response to Molecule of Bacterial Origin, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome