SLFN11 antibody

Catalog No. ABIN7270159

Product Details anti-SLFN11 Antibody

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SLFN11 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: SLFN11 Rabbit mAb

Cross-Reactivity: Human

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of human SLFN11.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SLFN11

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Alternative Name: SLFN11 (SLFN11 Products)

Synonyms: SLFN8/9 antibody, schlafen family member 11 antibody, SLFN11 antibody, LOC100071612 antibody

Background: Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Acts independently of ATR. Also acts as an interferon (IFN-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1 by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA.,SLFN8/9,SLFN11

Molecular Weight: 102kDa

Gene ID: 91607

UniProt: Q7Z7L1