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SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8) antibody

SARS-CoV NSP8 Reactivity: SARS Coronavirus-2 (SARS-CoV-2) IF, WB Host: Rabbit Monoclonal unconjugated
Catalog No. ABIN7270150
  • Target See all SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8) Antibodies
    SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8)
    Reactivity
    SARS Coronavirus-2 (SARS-CoV-2)
    Host
    • 1
    Rabbit
    Clonality
    • 1
    Monoclonal
    Conjugate
    • 1
    Un-conjugated
    Application
    Immunofluorescence (IF), Western Blotting (WB)
    Purpose
    SARS-CoV-2 3CLpro Rabbit mAb
    Cross-Reactivity
    SARS Coronavirus-2 (SARS-CoV-2)
    Characteristics
    Monoclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of SARS-CoV-2 3CLpro.
    Isotype
    IgG
    Top Product
    Discover our top product SARS-CoV NSP8 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8)
    Alternative Name
    3CLpro (SARS-CoV NSP8 Products)
    Synonyms
    pp1a antibody, pp1ab antibody, orf1ab polyprotein (pp1ab) antibody, orf1ab antibody
    Target Type
    Viral Protein
    Background
    [Spike protein S1]: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell. This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2. The stalk domain of S contains three hinges, giving the head unexpected orientational freedom. Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.,3CLpro
    Gene ID
    43740578
    UniProt
    P0DTC2
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