RNF185 antibody (AA 1-130)

Catalog No. ABIN7270068

Product Details anti-RNF185 Antibody

Target: RNF185 (Ring Finger Protein 185 (RNF185))

Binding Specificity: AA 1-130

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF185 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: RNF185 Rabbit pAb

Sequence: MASKGPSASA SPENSSAGGP SGSSNGAGES GGQDSTFECN ICLDTAKDAV ISLCGHLFCW PCLHQWLETR PNRQVCPVCK AGISRDKVIP LYGRGSTGQQ DPREKTPPRP QGQRPEPENR GGFQGFGFGD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RNF185 (NP_689480.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RNF185

Target: RNF185 (Ring Finger Protein 185 (RNF185))

Alternative Name: RNF185 (RNF185 Products)

Synonyms: zgc:73070 antibody, xrnf185 antibody, 1700022N24Rik antibody, AL033296 antibody, ring finger protein 185 antibody, ring finger protein 185 L homeolog antibody, rnf185 antibody, rnf185.L antibody, RNF185 antibody, Rnf185 antibody

Background: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER-associated degradation (ERAD pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.,RNF185,Cell Biology & Developmental Biology,RNF185

Molecular Weight: 14kDa/20kDa

Gene ID: 91445

UniProt: Q96GF1