PRR5 antibody (AA 109-388)

Catalog No. ABIN7269555

Product Details anti-PRR5 Antibody

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Binding Specificity: AA 109-388

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRR5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purpose: PRR5 Rabbit pAb

Sequence: QKLLDSLAET WDFFFSDVLP MLQAIFYPVQ GKEPSVRQLA LLHFRNAITL SVKLEDALAR AHARVPPAIV QMLLVLQGVH ESRGVTEDYL RLETLVQKVV SPYLGTYGLH SSEGPFTHSC ILEKRLLRRS RSGDVLAKNP VVRSKSYNTP LLNPVQEHEA EGAAAGGTSI RRHSVSEMTS CPEPQGFSDP PGQGPTGTFR SSPAPHSGPC PSRLYPTTQP PEQGLDPTRS SLPRSSPENL VDQILESVDS DSEGIFIDFG RGRGSGMSDL EGSGGRQSVV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 109-388 of human PRR5 (NP_851850.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PRR5

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Alternative Name: PRR5 (PRR5 Products)

Synonyms: AU043908 antibody, Arhgap8 antibody, C030017C09Rik antibody, C78947 antibody, Protor-1 antibody, Protor1 antibody, FLJ20185k antibody, PP610 antibody, PROTOR-1 antibody, PROTOR1 antibody, pp610 antibody, protor1 antibody, protor2 antibody, proline rich 5 (renal) antibody, proline rich 5 antibody, proline rich 5 L homeolog antibody, Prr5 antibody, PRR5 antibody, prr5.L antibody

Background: This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.,PRR5,FLJ20185k,PP610,PROTOR-1,PROTOR1,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Cancer,Tumor suppressors,Signal Transduction,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,PRR5

Molecular Weight: 31kDa/32kDa/41kDa/42kDa/45kDa

Gene ID: 55615

UniProt: P85299

Pathways: PI3K-Akt Signaling