This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010],H731,Apoptosis,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Cell Cycle_Cell cycle inhibitors,Epigenetics & Nuclear Signaling,Invasion and Metastasis,PI3K-Akt Signaling Pathway,Signal Transduction,Translation Control,Translational Control_Regulation of eIF4 and p70 S6 Kinase,PDCD4