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PRAME antibody (AA 1-200)
PRAME
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PRAME Antibody
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Target
See all PRAME Antibodies
PRAME
(Preferentially Expressed Antigen in Melanoma (PRAME))
Binding Specificity
All epitopes for PRAME antibodies
AA 1-200
Reactivity
All reactivities for PRAME antibodies
Human
Host
All hosts for PRAME antibodies
Rabbit
Clonality
All clonalities for PRAME antibodies
Polyclonal
Conjugate
All conjugates for PRAME antibodies
This PRAME antibody is un-conjugated
Application
All applications for PRAME antibodies
Western Blotting (WB)
Purpose
PRAME Rabbit pAb
Sequence
MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR ELFPPLFMAA FDGRHSQTLK AMVQAWPFTC LPLGVLMKGQ HLHLETFKAV LDGLDVLLAQ EVRPRRWKLQ VLDLRKNSHQ DFWTVWSGNR ASLYSFPEPE AAQPMTKKRK VDGLSTEAEQ PFIPVEVLVD LFLKEGACDE LFSYLIEKVK
Cross-Reactivity
Human, Mouse, Rat
Characteristics
Polyclonal Antibodies
Purification
Affinity purification
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PRAME (NP_006106.1).
Isotype
IgG
Top Product
Discover our top product PRAME Primary Antibody
Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for PRAME
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Target
PRAME
(Preferentially Expressed Antigen in Melanoma (PRAME))
Alternative Name
PRAME (PRAME Products )
Synonyms
PRAME antibody, CT130 antibody, MAPE antibody, OIP-4 antibody, OIP4 antibody, 4930534P07Rik antibody, preferentially expressed antigen in melanoma antibody, PRAME antibody, Prame antibody
Background
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.,PRAME,CT130,MAPE,OIP-4,OIP4,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Cancer,Tumor biomarkers,PRAME
Molecular Weight
57kDa
Gene ID
23532
UniProt
P78395
Pathways
Retinoic Acid Receptor Signaling Pathway , Nuclear Hormone Receptor Binding
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