PDE1C antibody (AA 435-634)

Catalog No. ABIN7269300

This anti-PDE1C antibody is a Rabbit Polyclonal antibody detecting PDE1C in WB. Suitable for Human.

Quick Overview for PDE1C antibody (AA 435-634) (ABIN7269300)

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE1C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE1C Antibody

Binding Specificity: AA 435-634

Purpose: PDE1C Rabbit pAb

Sequence: VEPTFTVLTD MTEKIVSPLI DETSQTGGTG QRRSSLNSIS SSDAKRSGVK TSGSEGSAPI NNSVISVDYK SFKATWTEVV HINRERWRAK VPKEEKAKKE AEEKARLAAE EQQKEMEAKS QAEEGASGKA EKKTSGETKN QVNGTRANKS DNPRGKNSKA EKSSGEQQQN GDFKDGKNKT DKKDHSNIGN DSKKTDDSQE

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 435-634 of human PDE1C (NP_001177985.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PDE1C

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Alternative Name: PDE1C

Background: This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta.,PDE1C,Hcam3,cam-PDE 1C,hCam-3,cam-PDE1C,Signal Transduction,PDE1C

Molecular Weight: 72kDa/80kDa/86kDa

Gene ID: 5137

UniProt: Q14123

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma