PAPD5 antibody (AA 480-590)

Catalog No. ABIN7269170

Product Details anti-PAPD5 Antibody

Target: PAPD5 (PAP Associated Domain Containing 5 (PAPD5))

Binding Specificity: AA 480-590

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAPD5 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: PAPD5 Rabbit pAb

Sequence: YYPNNETESI LGRIIRVTDE VATYRDWISK QWGLKNRPEP SCNGNGVTLI VDTQQLDKCN NNLSEENEAL GKCRSKTSES LSKHSSNSSS GPVSSSSATQ SSSSDVDSDA T

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 480-590 of human PAPD5 (NP_001035374.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PAPD5

Target: PAPD5 (PAP Associated Domain Containing 5 (PAPD5))

Alternative Name: PAPD5 (PAPD5 Products)

Synonyms: TRF4-2 antibody, LOC568678 antibody, 5730445M16Rik antibody, 5830428A09 antibody, poly(A) RNA polymerase D5, non-canonical antibody, PAP associated domain containing 5 antibody, PAP associated domain containing 5 L homeolog antibody, PAPD5 antibody, Papd5 antibody, papd5 antibody, CC1G_07969 antibody, papd5.L antibody

Background: Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A tail creating a heterogeneous 3' poly(A tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro. Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1. Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation. Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation.,PAPD5,TRF4-2,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Drug resistance,Topoisomerases,PAPD5

Molecular Weight: 41kDa/51kDa/63kDa/64kDa/75kDa

Gene ID: 64282

UniProt: Q8NDF8