wu:fj84d09 antibody, NFATC2IP antibody, D7Ertd304e antibody, NIP45 antibody, ESC2 antibody, RAD60 antibody, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein antibody, nuclear factor of activated T-cells 2 interacting protein antibody, nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein antibody, nfatc2ip antibody, NFATC2IP antibody, Nfatc2ip antibody
Background
In T-helper 2 (Th2 cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter, this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity.,NFATC2IP,ESC2,NIP45,RAD60,Epigenetics & Nuclear Signaling,Signal Transduction,Immunology & Inflammation,Cytokines,Cell Intrinsic Innate Immunity Signaling Pathway,NFATC2IP