This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors, they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011],BDCA4,CD304,NP1,NRP,VEGF165R,Neuropilin-1,NRP1,Angiogenesis,Cardiovascular,CDs,Cell Biology & Developmental Biology,Growth factors,Growth factors_VEGF,Growth factors_VEGF Receptors,Immunology & Inflammation,Neuroscience,Stem Cells,NRP1