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MTMR6 antibody (AA 382-621)

The Rabbit Polyclonal anti-MTMR6 antibody has been validated for WB. It is suitable to detect MTMR6 in samples from Human.
Catalog No. ABIN7268765

Quick Overview for MTMR6 antibody (AA 382-621) (ABIN7268765)

Target

See all MTMR6 Antibodies
MTMR6 (Myotubularin Related Protein 6 (MTMR6))

Reactivity

  • 25
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
Human

Host

  • 23
  • 2
Rabbit

Clonality

  • 25
Polyclonal

Conjugate

  • 16
  • 3
  • 2
  • 2
  • 1
  • 1
This MTMR6 antibody is un-conjugated

Application

  • 19
  • 13
  • 2
  • 1
  • 1
Western Blotting (WB)
  • Binding Specificity

    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 382-621

    Purpose

    MTMR6 Rabbit pAb

    Sequence

    RCGQLDGDPK EVSPVFTQFL ECVWHLTEQF PQAFEFSEAF LLQIHEHIHS CQFGNFLGNC QKEREELKLK EKTYSLWPFL LEDQKKYLNP LYSSESHRFT VLEPNTVSFN FKFWRNMYHQ FDRTLHPRQS VFNIIMNMNE QNKQLEKDIK DLESKIKQRK NKQTDGILTK ELLHSVHPES PNLKTSLCFK EQTLLPVNDA LRTIEGSSPA DNRYSEYAEE FSKSEPAVVS LEYGVARMTC

    Cross-Reactivity

    Human, Mouse, Rat

    Characteristics

    Polyclonal Antibodies

    Purification

    Affinity purification

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 382-621 of human MTMR6 (NP_004676.3).

    Isotype

    IgG
  • Application Notes

    WB,1:200 - 1:2000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    MTMR6 (Myotubularin Related Protein 6 (MTMR6))

    Alternative Name

    MTMR6

    Background

    Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3P and phosphatidylinositol 3,5-bisphosphate (Probable. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5P2 but also to phosphatidylinositol 3-phosphate (PtdIns(3P, phosphatidylinositol 4-phosphate (PtdIns(4P, and phosphatidylinositol 5-phosphate (PtdIns(5P, phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport (By similarity. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+ T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels.,MTMR6,Signal Transduction,MTMR6

    Molecular Weight

    63kDa/71kDa

    Gene ID

    9107

    UniProt

    Q9Y217

    Pathways

    Inositol Metabolic Process
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