GANP antibody (AA 250-550)

Catalog No. ABIN7268541

Product Details anti-GANP Antibody

Target: GANP (MCM3AP) (Minichromosome Maintenance Complex Component 3 Associated Protein (MCM3AP))

Binding Specificity: AA 250-550

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GANP antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: MCM3AP Rabbit pAb

Sequence: SSFPVSSAVL GEPFQASKAG VRQGCEEAVS QVEPLPSLMK GLKRKEDQDR SPRRHGHEPA EDSDPLSRGD HPPDKRPVRL NRPRGGTLFG RTIQDVFKSN KEVGRLGNKE AKKETGFVES AESDHMAIPG GNQSVLAPSR IPGVNKEEET ESREKKEDSL RGTPARQSNR SESTDSLGGL SPSEVTAIQC KNIPDYLNDR TILENHFGKI AKVQRIFTRR SKKLAVVHFF DHASAALARK KGKSLHKDMA IFWHRKKISP NKKPFSLKEK KPGDGEVSPS TEDAPFQHSP LGKAAGRTGA S

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human MCM3AP (NP_003897.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GANP

Target: GANP (MCM3AP) (Minichromosome Maintenance Complex Component 3 Associated Protein (MCM3AP))

Alternative Name: MCM3AP (MCM3AP Products)

Synonyms: GANP antibody, MAP80 antibody, SAC3 antibody, mKIAA0572 antibody, minichromosome maintenance complex component 3 associated protein antibody, germinal-center associated nuclear protein antibody, Mcm3ap antibody, MCM3AP antibody, mcm3ap antibody, LOC100026233 antibody

Background: The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability.,MCM3AP,GANP,MAP80,SAC3,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,Cell differentiation,MCM3AP

Molecular Weight: 80kDa/218kDa

Gene ID: 8888

UniProt: O60318

Pathways: Protein targeting to Nucleus