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MICA antibody

MICA Reactivity: Human WB Host: Rabbit Monoclonal unconjugated
Catalog No. ABIN7268508
  • Target See all MICA Antibodies
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Reactivity
    • 69
    • 18
    • 14
    • 11
    • 7
    • 5
    • 2
    • 1
    Human
    Host
    • 36
    • 33
    Rabbit
    Clonality
    • 37
    • 33
    Monoclonal
    Conjugate
    • 44
    • 8
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MICA antibody is un-conjugated
    Application
    • 44
    • 37
    • 33
    • 19
    • 17
    • 12
    • 9
    • 8
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    MICA Rabbit mAb
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Monoclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant protein of human MICA.
    Isotype
    IgG
    Top Product
    Discover our top product MICA Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Alternative Name
    MICA (MICA Products)
    Synonyms
    MIC-A antibody, PERB11.1 antibody, MHC class I polypeptide-related sequence A antibody, MICA antibody
    Background
    This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.,MICA, MIC-A, PERB11.1, MHC class I polypeptide-related sequence A,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,MICA
    Molecular Weight
    42-70kDa
    Gene ID
    100507436
    UniProt
    Q29983
    Pathways
    Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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