LAPTM4B antibody (AA 218-317)

Catalog No. ABIN7268341

Product Details anti-LAPTM4B Antibody

Target: LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))

Binding Specificity: AA 218-317

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAPTM4B antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: LAPTM4B Rabbit pAb

Sequence: NSIQEYIRQL PPNFPYRDDV MSVNPTCLVL IILLFISIIL TFKGYLISCV WNCYRYINGR NSSDVLVYVT SNDTTVLLPP YDDATVNGAA KEPPPPYVSA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 218-317 of human LAPTM4B (NP_060877.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LAPTM4B

Target: LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))

Alternative Name: LAPTM4B (LAPTM4B Products)

Synonyms: LAPTM4beta antibody, LC27 antibody, C330023P13Rik antibody, lysosomal protein transmembrane 4 beta antibody, lysosomal-associated protein transmembrane 4B antibody, LAPTM4B antibody, Laptm4b antibody

Background: Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter to the lysosome, promoting entry of leucine and other essential amino acid (EAA into the lysosome, stimulating activation of proton-transporting vacuolar (V-ATPase protein pump (V-ATPase and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.,LAPTM4B,LAPTM4beta,LC27,Cancer,Tumor biomarkers,LAPTM4B

Molecular Weight: 25kDa/35kDa/41kDa

Gene ID: 55353

UniProt: Q86VI4