LDLR antibody (C-Term)

Catalog No. ABIN7268296

Product Details anti-LDLR Antibody

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LDLR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purpose: [KO Validated] LDL Receptor (LDLR) Rabbit pAb

Sequence: VFLCLGVFLL WKNWRLKNIN SINFDNPVYQ KTTEDEVHIC HNQDGYSYPS RQMVSLEDDV A

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Grade: KO Validated

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human LDL Receptor (LDLR) (NP_000518.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Alternative Name: LDLR (LDLR Products)

Synonyms: FH antibody, FHC antibody, LDLCQ2 antibody, Hlb301 antibody, LDLRA antibody, LDLA antibody, LDL receptor-2 antibody, fhc antibody, ldlcq2 antibody, ldlr antibody, ldlr2-a antibody, LDL receptor 1 antibody, ldlr-a antibody, ldlr-b antibody, low density lipoprotein receptor antibody, low density lipoprotein receptor a antibody, low density lipoprotein receptor S homeolog antibody, low density lipoprotein receptor L homeolog antibody, LDLR antibody, Ldlr antibody, ldlra antibody, ldlr.S antibody, ldlr.L antibody

Background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.,LDLR,FH,FHC,LDLCQ2,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,LDLR

Molecular Weight: 75kDa/76kDa/82kDa/90kDa/95kDa

Gene ID: 3949

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism