LRRFIP2 antibody (AA 150-340)

Catalog No. ABIN7268214

Product Details anti-LRRFIP2 Antibody

Target: LRRFIP2 (Leucine Rich Repeat (In FLII) Interacting Protein 2 (LRRFIP2))

Binding Specificity: AA 150-340

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRFIP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: LRRFIP2 Rabbit pAb

Sequence: VIEEQEEQMA EFYRENEEKS KELERQKHMC SVLQHKMEEL KEGLRQRDEL IEKHGLVIIP DGTPNGDVSH EPVAGAITVV SQEAAQVLES AGEGPLDVRL RKLAGEKEEL LSQIRKLKLQ LEEERQKCSR NDGTVGDLAG LQNGSDLQFI EMQRDANRQI SEYKFKLSKA EQDITTLEQS ISRLEGQVLR Y

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 150-340 of human LRRFIP2 (NP_060194.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LRRFIP2

Target: LRRFIP2 (Leucine Rich Repeat (In FLII) Interacting Protein 2 (LRRFIP2))

Alternative Name: LRRFIP2 (LRRFIP2 Products)

Background: The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex.,LRRFIP2,HUFI-2,Epigenetics & Nuclear Signaling,Signal Transduction,Immunology & Inflammation,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TLR Signaling,Stem Cells,LRRFIP2

Gene ID: 9209

UniProt: Q9Y608