Laminin gamma 1 antibody (AA 1300-1609)

Catalog No. ABIN7268186

Product Details anti-Laminin gamma 1 Antibody

Target: Laminin gamma 1 (LAMC1) (Laminin, gamma 1 (LAMC1))

Binding Specificity: AA 1300-1609

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Laminin gamma 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: LAMC1 Rabbit pAb

Sequence: IDQKLKDYED LREDMRGKEL EVKNLLEKGK TEQQTADQLL ARADAAKALA EEAAKKGRDT LQEANDILNN LKDFDRRVND NKTAAEEALR KIPAINQTIT EANEKTREAQ QALGSAAADA TEAKNKAHEA ERIASAVQKN ATSTKAEAER TFAEVTDLDN EVNNMLKQLQ EAEKELKRKQ DDADQDMMMA GMASQAAQEA EINARKAKNS VTSLLSIIND LLEQLGQLDT VDLNKLNEIE GTLNKAKDEM KVSDLDRKVS DLENEAKKQE AAIMDYNRDI EEIMKDIRNL EDIRKTLPSG CFNTPSIEKP

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1300-1609 of human LAMC1 (NP_002284.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Laminin gamma 1

Target: Laminin gamma 1 (LAMC1) (Laminin, gamma 1 (LAMC1))

Alternative Name: LAMC1 (LAMC1 Products)

Synonyms: lamb2 antibody, Lamb2 antibody, B2e antibody, sly antibody, LAMB2 antibody, putative laminin gamma-1 chain antibody, laminin subunit gamma 1 antibody, laminin, gamma 1 antibody, Smp_163810 antibody, lamc1 antibody, Lamc1 antibody, LAMC1 antibody

Background: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma. Some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.,LAMC1,LAMB2,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Neuroscience,Neurodegenerative Diseases,LAMC1

Molecular Weight: 177kDa

Gene ID: 3915

UniProt: P11047