KIF5B antibody (AA 650-770)

Catalog No. ABIN7268136

Product Details anti-KIF5B Antibody

Target: KIF5B (Kinesin Family Member 5B (KIF5B))

Binding Specificity: AA 650-770

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIF5B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purpose: KIF5B Rabbit pAb

Sequence: LQNVEQKKRQ LEESVDALSE ELVQLRAQEK VHEMEKEHLN KVQTANEVKQ AVEQQIQSHR ETHQKQISSL RDEVEAKAKL ITDLQDQNQK MMLEQERLRV EHEKLKATDQ EKSRKLHELT V

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 650-770 of human KIF5B (NP_004512.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for KIF5B

Target: KIF5B (Kinesin Family Member 5B (KIF5B))

Alternative Name: KIF5B (KIF5B Products)

Synonyms: KINH antibody, KNS antibody, KNS1 antibody, UKHC antibody, Khc antibody, AL022807 antibody, Khcs antibody, Kns1 antibody, Ukhc antibody, khc antibody, KIF5A antibody, kinesin family member 5B antibody, kinesin heavy chain antibody, kinesin-1 antibody, kinesin-1 heavy chain antibody, kinesin family member 5B S homeolog antibody, KIF5B antibody, LOC411769 antibody, cgd6_2790 antibody, kin-1 antibody, Tb927.1.1350 antibody, LACBIDRAFT_305999 antibody, Khc antibody, LOC100538629 antibody, Kif5b antibody, kif5b.S antibody

Background: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity. Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable. Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs toward the immune synapse between effector NK lymphocytes and target cells.,KIF5B,HEL-S-61,KINH,KNS,KNS1,UKHC,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Motor Proteins,KIF5B

Molecular Weight: 109kDa

Gene ID: 3799

UniProt: P33176

Pathways: Peptide Hormone Metabolism, Ribonucleoprotein Complex Subunit Organization