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INSIG1 antibody (C-Term)

INSIG1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7267887
  • Target See all INSIG1 Antibodies
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Binding Specificity
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 28
    • 9
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 28
    Rabbit
    Clonality
    • 28
    Polyclonal
    Conjugate
    • 16
    • 4
    • 2
    • 2
    • 2
    • 2
    This INSIG1 antibody is un-conjugated
    Application
    • 24
    • 17
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Purpose
    INSIG1 Rabbit pAb
    Sequence
    LWWTFDRSRS GLGLGITIAF LATLITQFLV YNGVYQYTSP DFLYIRSWLP CIFFSGGVTV GNIGRQLAMG VPEKPHSD
    Cross-Reactivity
    Human, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human INSIG1 (NP_005533.2).
    Isotype
    IgG
    Top Product
    Discover our top product INSIG1 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Alternative Name
    INSIG1 (INSIG1 Products)
    Synonyms
    cl-6 antibody, cl6 antibody, CL-6 antibody, CL6 antibody, fb55a03 antibody, fi35b10 antibody, wu:fb55a03 antibody, wu:fi35b10 antibody, zgc:55439 antibody, 1810013C12Rik antibody, Insig-1 antibody, INSIG-1 antibody, insulin induced gene 1 antibody, insulin induced gene 1 L homeolog antibody, INSIG1 antibody, insig1 antibody, insig1.L antibody, Insig1 antibody
    Background
    This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.,INSIG1,CL6,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Lipids,INSIG1
    Molecular Weight
    17kDa/29kDa
    Gene ID
    3638
    UniProt
    O15503
    Pathways
    ER-Nucleus Signaling
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