IGHG1 antibody

Catalog No. ABIN7267844

Product Details anti-IGHG1 Antibody

Target: IGHG1 (Immunoglobulin Heavy Constant gamma 1 (G1m Marker) (IGHG1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This IGHG1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: Human IgG Rabbit mAb

Cross-Reactivity: Human

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Human IgG

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IGHG1

Target: IGHG1 (Immunoglobulin Heavy Constant gamma 1 (G1m Marker) (IGHG1))

Alternative Name: IGHG1 (IGHG1 Products)

Synonyms: RGD1359539 antibody, IgG1 antibody, Igh-4 antibody, VH7183 antibody, immunoglobulin heavy constant gamma 1 antibody, immunoglobulin heavy constant gamma 1 (G1m marker) antibody, Ighg1 antibody, IGHG1 antibody

Background: As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75 % of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity.,Immunology & Inflammation,IGHG1

Molecular Weight: 52kDa

Gene ID: 3500

UniProt: P01857, P01859, P01860, P01861