HERC5 antibody (AA 360-700)

Catalog No. ABIN7267596

Product Details anti-HERC5 Antibody

Target: HERC5 (Hect Domain and RLD 5 (HERC5))

Binding Specificity: AA 360-700

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HERC5 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: HERC5 Rabbit pAb

Sequence: ELIMIAGGNQ SILLWIKKEN SYVNLKRTIP TLNEGTVKRW IADVETKRWQ STKREIQEIF SSPACLTGSF LRKRRTTEMM PVYLDLNKAR NIFKELTQKD WITNMITTCL KDNLLKRLPF HSPPQEALEI FFLLPECPMM HISNNWESLV VPFAKVVCKM SDQSSLVLEE YWATLQESTF SKLVQMFKTA VICQLDYWDE SAEENGNVQA LLEMLKKLHR VNQVKCQLPE SIFQVDELLH RLNFFVEVCR RYLWKMTVDA SENVQCCVIF SHFPFIFNNL SKIKLLHTDT LLKIESKKHK AYLRSAAIEE ERESEFALRP TFDLTVRRNH LIEDVLNQLS Q

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 360-700 of human HERC5 (NP_057407.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HERC5

Target: HERC5 (Hect Domain and RLD 5 (HERC5))

Alternative Name: HERC5 (HERC5 Products)

Background: This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.,HERC5,CEB1,CEBP1,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,Ubiquitin,Immunology & Inflammation,Cytokines,Interferons,Cell Intrinsic Innate Immunity Signaling Pathway,HERC5

Molecular Weight: 116kDa

Gene ID: 51191

UniProt: Q9UII4