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GPX4 antibody

KO Validated GPX4 Reactivity: Human WB, IP Host: Rabbit Monoclonal unconjugated
Catalog No. ABIN7267436
  • Target See all GPX4 Antibodies
    GPX4 (Glutathione Peroxidase 4 (GPX4))
    Reactivity
    • 51
    • 42
    • 37
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 51
    • 4
    • 1
    Rabbit
    Clonality
    • 44
    • 12
    Monoclonal
    Conjugate
    • 24
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GPX4 antibody is un-conjugated
    Application
    • 33
    • 18
    • 17
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Purpose
    [KO Validated] GPX4 Rabbit mAb
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Monoclonal Antibodies
    Purification
    Affinity purification
    Grade
    KO Validated
    Immunogen
    A synthesized peptide derived from human GPX4
    Isotype
    IgG
    Top Product
    Discover our top product GPX4 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IP,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    GPX4 (Glutathione Peroxidase 4 (GPX4))
    Alternative Name
    GPX4 (GPX4 Products)
    Synonyms
    GPx-4 antibody, GSHPx-4 antibody, MCSP antibody, PHGPx antibody, snGPx antibody, snPHGPx antibody, Phgpx antibody, gpx-4 antibody, snGpx antibody, cb563 antibody, cb691 antibody, PHGPxa antibody, sb:cb563 antibody, zgc:92253 antibody, wu:fb82e03 antibody, 1700027O09Rik antibody, mtPHGPx antibody, ATGPX4 antibody, F11L15.5 antibody, glutathione peroxidase 4 antibody, GP-GPx4 antibody, glutathione peroxidase 4 antibody, glutathione peroxidase 4a antibody, GPX4 antibody, Gpx4 antibody, gpx4a antibody
    Background
    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016],GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx,Cancer,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial metabolism_Mitochondrial markers,Signal Transduction,GPX4
    Molecular Weight
    19kDa/22kDa
    Gene ID
    2879
    UniProt
    P36969
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