EARS2 antibody (AA 42-220)

Catalog No. ABIN7267433

Product Details anti-EARS2 Antibody

Target: EARS2 (Glutamyl-tRNA Synthetase 2 Mitochondrial (EARS2))

Binding Specificity: AA 42-220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EARS2 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: EARS2 Rabbit pAb

Sequence: APSPTGFLHL GGLRTALYNY IFAKKYQGSF ILRLEDTDQT RVVPGAAENI EDMLEWAGIP PDESPRRGGP AGPYQQSQRL ELYAQATEAL LKTGAAYPCF CSPQRLELLK KEALRNHQTP RYDNRCRNMS QEQVAQKLAK DPKPAIRFRL EQVVPAFQDL VYGWNRHEVA SVEGDPVIM

Cross-Reactivity: Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 42-220 of human EARS2 (NP_001295140.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EARS2

Target: EARS2 (Glutamyl-tRNA Synthetase 2 Mitochondrial (EARS2))

Alternative Name: EARS2 (EARS2 Products)

Background: This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants.,EARS2,COXPD12,MSE1,gluRS,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Mitochondrial translation,Nucleotide metabolism,EARS2

Molecular Weight: 58kDa/59kDa

Gene ID: 124454

UniProt: Q5JPH6