GIT2 antibody (AA 450-510)

Catalog No. ABIN7267315

Product Details anti-GIT2 Antibody

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Binding Specificity: AA 450-510

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIT2 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: GIT2 Rabbit pAb

Sequence: ASRLEKQNST PESDYDNTPN DMEPDGMGSS RKGRQRSMVW PGDGLVPDTA EPHVAPSPTL P

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 450-510 of human GIT2 (NP_476511.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GIT2

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Alternative Name: GIT2 (GIT2 Products)

Synonyms: CAT-2 antibody, CAT2 antibody, cat-2 antibody, xgit2 antibody, git2 antibody, si:dkey-234h16.4 antibody, 1500036H07Rik antibody, 5830420E16Rik antibody, 6430510B20Rik antibody, 9630056M03Rik antibody, B230104M05Rik antibody, mKIAA0148 antibody, zgc:158416 antibody, GIT ArfGAP 2 antibody, G protein-coupled receptor kinase interacting ArfGAP 2 antibody, G protein-coupled receptor kinase interacting ArfGAP 2a antibody, G protein-coupled receptor kinase-interactor 2 antibody, G protein-coupled receptor kinase interacting ArfGAP 2 L homeolog antibody, G protein-coupled receptor kinase interacting ArfGAP 2b antibody, GIT2 antibody, git2 antibody, git2a antibody, Git2 antibody, git2.L antibody, git2b antibody

Background: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.,GIT2,CAT-2,CAT2,PKL,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Kinase,Cell Biology & Developmental Biology,Cytoskeleton,Actins,GIT2

Molecular Weight: 52kDa, 70-84kDa

Gene ID: 9815

UniProt: Q14161

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling