G protein-coupled receptor 4 antibody, GPR4 antibody, Gpr4 antibody
Background
Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC, and GNA12/GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2H(+ (By similarity.,GPR4,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),GPR4