FEM1A antibody (AA 100-300)

Catalog No. ABIN7267165

Product Details anti-FEM1A Antibody

Target: FEM1A (Fem-1 Homolog A (FEM1A))

Binding Specificity: AA 100-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FEM1A antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: FEM1A Rabbit pAb

Sequence: RSLLRRGASV NRTTRTNSTP LRAACFDGHL EVVRYLVGEH QADLEVANRH GHTCLMISCY KGHREIARYL LEQGAQVNRR SAKGNTALHD CAESGSLEIL QLLLGCKARM ERDGYGMTPL LAASVTGHTN IVEYLIQEQP GQEQVAGGEA QPGLPQEDPS TSQGCAQPQG APCCSSSPEE PLNGESYESC CPTSREAAVE A

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human FEM1A (NP_061178.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FEM1A

Target: FEM1A (Fem-1 Homolog A (FEM1A))

Alternative Name: FEM1A (FEM1A Products)

Synonyms: EPRAP antibody, fi20c04 antibody, wu:fi20c04 antibody, zgc:63483 antibody, AW611390 antibody, Fem1aa antibody, fem-1 homolog A antibody, fem-1 homolog a (C. elegans) antibody, feminization 1 homolog a (C. elegans) antibody, FEM1A antibody, Fem1a antibody, fem1a antibody

Background: Substrate-recognition component of a Cul2-RING (CRL2 E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity.,FEM1A,EPRAP,Cell Biology & Developmental Biology,Apoptosis,Caspases,FEM1A

Molecular Weight: 73kDa

Gene ID: 55527

UniProt: Q9BSK4