This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008],EPLG5, HTKL, Htk-L, LERK5,Angiogenesis,Angiogenesis_Angiogenic growth factors,Cancer,Cardiovascular,Cell Biology & Developmental Biology,Cell Type Marker,Cell Type Marker_Growth Cone,Cell Type Marker_Neuron marker,Growth factors,Invasion and Metastasis,Kinase,Neuroscience,EFNB2