CAND1 antibody (AA 750-980)

Catalog No. ABIN7266546

Product Details anti-CAND1 Antibody

Target: CAND1 (Cullin-Associated and Neddylation-Dissociated 1 (CAND1))

Binding Specificity: AA 750-980

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAND1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: CAND1 Rabbit pAb

Sequence: GALSAMLDFF QALVVTGTNN LGYMDLLRML TGPVYSQSTA LTHKQSYYSI AKCVAALTRA CPKEGPAVVG QFIQDVKNSR STDSIRLLAL LSLGEVGHHI DLSGQLELKS VILEAFSSPS EEVKSAASYA LGSISVGNLP EYLPFVLQEI TSQPKRQYLL LHSLKEIISS ASVVGLKPYV ENIWALLLKH CECAEEGTRN VVAECLGKLT LIDPETLLPR LKGYLISGSS Y

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 750-980 of human CAND1 (NP_060918.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CAND1

Target: CAND1 (Cullin-Associated and Neddylation-Dissociated 1 (CAND1))

Alternative Name: CAND1 (CAND1 Products)

Background: This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants.,CAND1,TIP120,TIP120A,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Ubiquitin,CAND1

Molecular Weight: 45kDa/117kDa/136kDa

Gene ID: 55832

UniProt: Q86VP6

Pathways: Regulation of Actin Filament Polymerization