C6orf150 antibody (pSer420)

Catalog No. ABIN7266387

Product Details anti-C6orf150 Antibody

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Binding Specificity: pSer420

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C6orf150 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Phospho-CGAS-S420 Rabbit pAb

Cross-Reactivity: Human, Rat

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A phospho synthetic peptide corresponding to residues surrounding S420 of Mouse CGAS.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for C6orf150

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Alternative Name: CGAS (C6orf150 Products)

Synonyms: C6orf150 antibody, cGAS antibody, h-cGAS antibody, Mab-21 domain containing 1 antibody, cyclic GMP-AMP synthase antibody, MB21D1 antibody, CGAS antibody

Background: The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],E330016A19Rik, cGAS,CGAS

Gene ID: 214763

UniProt: Q8C6L5

Pathways: Activation of Innate immune Response