CCR7 antibody (AA 1-100)

Catalog No. ABIN7266310

Product Details anti-CCR7 Antibody

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Binding Specificity: AA 1-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR7 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purpose: CCR7 Rabbit pAb

Sequence: MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR7 (NP_001829.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CCR7

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Alternative Name: CCR7 (CCR7 Products)

Background: The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.,CCR7,BLR2,CC-CKR-7,CCR-7,CD197,CDw197,CMKBR7,EBI1,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Immunology & Inflammation,CD markers,Cell Intrinsic Innate Immunity Signaling Pathway,Chemokines,Chemokine,CCR7

Molecular Weight: 42kDa

Gene ID: 1236

UniProt: P32248

Pathways: Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process