CENPE antibody (AA 2542-2701)

Catalog No. ABIN7266274

Product Details anti-CENPE Antibody

Target: CENPE (Centromere Protein E, 312kDa (CENPE))

Binding Specificity: AA 2542-2701

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CENPE antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: CENPE Rabbit pAb

Sequence: ALILKSEHIR LEKEISKLKQ QNEQLIKQKN ELLSNNQHLS NEVKTWKERT LKREAHKQVT CENSPKSPKV TGTASKKKQI TPSQCKERNL QDPVPKESPK SCFFDSRSKS LPSPHPVRYF DNSSLGLCPE VQNAGAESVD SQPGPWHASS GKDVPECKTQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2542-2701 of human CENPE (NP_001804.2).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CENPE

Target: CENPE (Centromere Protein E, 312kDa (CENPE))

Alternative Name: CENPE (CENPE Products)

Synonyms: CENP-E antibody, KIF10 antibody, PPP1R61 antibody, 312kDa antibody, AU019344 antibody, BC049989 antibody, C530022J18 antibody, Kif10 antibody, CENPE antibody, kif10 antibody, cenp-E antibody, XCENP-E antibody, wu:fc06a10 antibody, zgc:152925 antibody, centromere protein E antibody, centromere protein E, 312kDa antibody, CENPE antibody, Cenpe antibody, cenpe antibody

Background: Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.,CENPE,CENP-E,KIF10,MCPH13,PPP1R61,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Centromere,CENPE

Molecular Weight: 301kDa/312kDa/316kDa

Gene ID: 1062

UniProt: Q02224

Pathways: M Phase, Maintenance of Protein Location