Cathepsin L antibody

Catalog No. ABIN7266150

Product Details anti-Cathepsin L Antibody

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Cathepsin L antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: Cathepsin L/V/K/H Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Cathepsin L/V/K/H

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Cathepsin L

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Alternative Name: CTSL (CTSL1 Products)

Background: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012],CATL, CTSL1, MEP,Cell Adhesion,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Neuroscience,Signal Transduction,CTSL

Molecular Weight: 38kDa

Gene ID: 1514

UniProt: P07711, O60911, P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades