CARD16 antibody (AA 50-150)

Catalog No. ABIN7266127

Product Details anti-CARD16 Antibody

Target: CARD16 (Caspase Recruitment Domain Family, Member 16 (CARD16))

Binding Specificity: AA 50-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CARD16 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: CARD16 Rabbit pAb

Sequence: VMDKTRALID SVIPKGAQAC QICITYICEE DSYLAETLGL SAALQAVQDN PAMPTCSSPE GRIKLCFLED AQRIWKQKLQ RCHVQNTIIK WSERYTSGSF E

Cross-Reactivity: Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CARD16 (NP_001017534.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CARD16

Target: CARD16 (Caspase Recruitment Domain Family, Member 16 (CARD16))

Alternative Name: CARD16 (CARD16 Products)

Synonyms: COP antibody, COP1 antibody, PSEUDO-ICE antibody, caspase recruitment domain family member 16 antibody, CARD16 antibody

Background: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.,CARD16,COP,COP1,PSEUDO-ICE,Cell Biology & Developmental Biology,Apoptosis,Caspases,CARD16

Molecular Weight: 10kDa/22kDa

Gene ID: 114769

UniProt: Q5EG05