FLASH antibody (AA 1733-1982)

Catalog No. ABIN7266108

Product Details anti-FLASH Antibody

Target: FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))

Binding Specificity: AA 1733-1982

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLASH antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: CASP8AP2 Rabbit pAb

Sequence: TVGAFIDLTQ DASSEAKSEG NHPALAVEDL GCGVIQVDED NCKEEKAQVA NRPLKCIVEE TYIDLTTESP SSCEVKKDEL KSEPGSNCDN SELPGTLHNS HKKRRNISDL NHPHKKQRKE TDLTNKEKTK KPTQDSCENT EAHQKKASKK KAPPVTKDPS SLKATPGIKD SSAALATSTS LSAKNVIKKK GEIIILWTRN DDREILLECQ KRGPSFKTFA YLAAKLDKNP NQVSERFQQL MKLFEKSKCR

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1733-1982 of human CASP8AP2 (NP_036247.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FLASH

Target: FLASH (CASP8AP2) (CASP8 Associated Protein 2 (CASP8AP2))

Alternative Name: CASP8AP2 (CASP8AP2 Products)

Background: This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.,CASP8AP2,CED-4,FLASH,RIP25,Cell Biology & Developmental Biology,Apoptosis,CASP8AP2

Molecular Weight: 222kDa

Gene ID: 9994

UniProt: Q9UKL3

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity