This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants.,CREB3L3,CREB-H,CREBH,HYST1481,Epigenetics & Nuclear Signaling,Transcription Factors,Neuroscience,Neurodegenerative Diseases,CREB3L3