PRUNE antibody (AA 201-300) (Biotin)

Catalog No. ABIN717088

Product Details anti-PRUNE Antibody (Biotin)

Target: PRUNE (Prune Exopolyphosphatase (PRUNE))

Binding Specificity: AA 201-300

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRUNE antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DRES17

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PRUNE

Target: PRUNE (Prune Exopolyphosphatase (PRUNE))

Alternative Name: DRES17 (PRUNE Products)

Synonyms: PRUNE antibody, DRES-17 antibody, DRES17 antibody, HTCD37 antibody, 9230112O05Rik antibody, C130058A12 antibody, PRUNEM1 antibody, Prune-M1 antibody, prune exopolyphosphatase antibody, prune exopolyphosphatase 1 antibody, PRUNE1 antibody, Prune1 antibody

Background:

Synonyms: DRES17, Drosophila-related expressed sequence 17, hprune, HTCD37, Prune homolog, PRUNE like protein, TcD37 homolog, PRUNE_HUMAN.

Background: PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune, h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness.

Gene ID: 58497