Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A, MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008],APG10, APG10L, pp12616,Autophagy,Autophagy_ATGs,Cancer,Cardiovascular,Cell Biology & Developmental Biology,Endocrine & Metabolism,Heart,Neurodegenerative Diseases,Neuroscience,Tumor suppressors,Ubiquitin,ATG10